Community Newsletter: Autism Gene Lists, Genetic Diversity in Mouse Models, Autism Biomarker | Domain

Illustration of two scientists carrying a strand of DNA larger than life on their shoulders.

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Starting Things This Week is a topic by jonathan slumberprofessor of psychiatry and cellular and molecular medicine at the University of California, San Diego, calls autism research Focus on gene lists.

He tweeted that there is a lot to understand “about genes -> mechanisms -> phenotype in humans that requires it Well-supported human studies. But somehow human research has been reduced to “studies that produce gene lists”. Spatt further explained, “Once the gene is found, the human genes are an afterthought. I have news for you.” One gene does not cause autism. Genetics is just as important in translation! “

He replied, “With all these genetic lists, we have hundreds and hundreds of genes for job descriptions.” Maddy Gilentin, a geneticist at Seattle Children’s Hospital in Washington. She also noted the high cost and difficulty of designing studies that will affect a large number of genetic conditions.

Spat replied, “Clinical studies should not focus on one or two disorders. It is a major scientific problem that requires large-scale collaboration.”

Michael Gundalassistant professor of psychiatry and biobehavioral sciences at the University of California, Los Angeles, tweeted agreeing that ” master lesson Human genetics taught us that sample size is critical for a robust assessment of allelic influences in the population.”

in a separate topic, Joseph GleesonProfessor of Neurosciences at the University of California, San Diego, unpublished post study that used 33 genetically diverse strains of mice to model mutations in CHD8It is one of the candidate genes for autism.

Gleeson tweeted that the paper “reveals the susceptibility and resilience of individual breeds to # traits related to autism. “

“As this study and others show so well, important aspects of biology and disease are overlooked with a unitary focus on one dynastyhe answered Mark ZylkaProfessor of Cell Biology and Physiology at the University of North Carolina at Chapel Hill.

“Grateful to work with Pat and Alison and Ali Pioneering work This study made possible,” tweeted study author Manal Al-Tabbaa, a behavioral researcher at the University of Southern California in Los Angeles.

on another topic, James Mac BartlandProfessor of Child Psychiatry and Psychology at Yale University Child Studies Center study which use electroencephalography (EEG) to track children’s brain responses at rest and during many tasks. A delay in the brain’s response to seeing faces – called N170 – distinguishes children with autism from their non-autistic peers.

The results “provide information about the performance of the EEG biomarker relevant to the next stage of EEG development of vital signs Efforts focus on context of use,” according to the study.

Long-awaited EEG results from #ABCCT are finally published, showing up beautiful Strong psychological measurementsZack Williams, a medical student and doctoral student at Vanderbilt University in Nashville, Tennessee, wrote in a quoted tweet.

Continuing on the same topic, Williams tweeted, “The N170 ERP in particular has great potential as a ‘stratification biomarker’ that can be used in Subgroup of people with autism into groups that are potentially more biologically homogeneous, facilitating the discovery of treatment effects in clinical trials. “

Twitter user Tweet embed He raised the concern that “instead of stratification, this would become a means of excluding people on the basis of”Vital signs“Discovered from biased samples.”

That’s it in this week’s community newsletter! If you have any suggestions for interesting social posts you’ve seen in the field of autism research, feel free to send an email to [email protected].

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